This suggests that deficiency of vitamin B12 may also contribute to the increase of Hcy in psoriasis. One proposed mechanism of decreased folate in psoriasis may associated with inflammatory changes in intestinal mucosa, which causes reduced absorption of dietary folate . Another rational explanation may be related to rapid skin turn over in psoriasis with subsequent increased consumption of folate leading to low serum folate .
A number of studies have showed that consumption of alcohol correlates with elevated plasma/serum Hcy [32–40]. Therefore, smoking and alcohol consumption can be proposed as common factors between HHcy and psoriasis. Lower levels of vitamin B12 were found in patients with HHcy compared with patients with a normal value of Hcy .
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This is due to some antimicrobial factors that are overexpressed in the skin of those with psoriasis. Our website services, content, and products are for informational purposes only. Healthline Media does not provide medical advice, diagnosis, or treatment. Remember that while these home remedies for psoriasis may help with mild cases, prescription therapy is required for more severe cases. Talk to your doctor before seeking treatment on your own.
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- Prevent hand-foot-and-mouth disease It’s contagious, but you can reduce your child’s risk of catching it.
- When you have psoriasis, a problem with your immune system causes your body to produce too many skin cells, and it does so at a rate of production that’s too rapid.
- Instead, they would determine the severity of the disease based on the number of scaly patches a person had.
- Apply an over-the-counter itch-relieving product containing ingredients such as calamine, hydrocortisone, camphor, benzocaine, or menthol.
- Check with your doctor first, though, because some anti-itch products can worsen skin irritation.
Psoriasis is a chronic inflammatory disease with a worldwide prevalence of 2–3% . Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors . Therefore, the relation between psoriasis and homocysteine has attracted attention. Regular exercise may also help maintain a healthy immune system. What makes this even more puzzling is that people with psoriasis inherently have a lower risk for certain skin infections.
In human body, approximately 50% of Hcy is re-methylated to form methionine, and this remethylation reaction requires a folate coenzyme. Thus, folic acid deficiency can result in a buildup of Hcy. The increase of Hcy can be caused by the decrease of folic acid. In psoriasis, lack of folic acid and vitamin B12 can be a cause of HHcy, while smoking, alcohol consumption, and obesity are associated factors.
For example, a H2S donor—sodium hydrosulfide significantly reduced concentration of Hcy in rats with HHcy . The Hcy lowering effect of H2S donor could result from the stimulation of the trans-sulphuration pathway by activating CSE sickle cell anemia symptoms and CBS.
For example, administration of NaHS significantly up-regulates the gene expression of CSE and GSH in C2C12 mouse myotubes. It is well known that dendritic cells play a major role in the initial stages of psoriasis. Reactive oxygen species may play an important role in activation of DCs and increase the DC ability to activate CD4+ T cells . Oxidative stress has been suggested as a primary mechanism responsible for HHcy-related pathogenesis . Therefore in psoriasis, increased Hcy may facilitate the disease initiation and maintenance via increasing DC activation by ROS.